个人信息

博士生导师
研究员
2018年获得“国家杰出青年基金”
Email: htliu@cemps.ac.cn
个人网页: http://lht.cemps.ac.cn

研究方向

光信号转导

刘宏涛

个人简介

20029-20057月,河北师范大学,研究生/博士
2005
9-20109月,美国加州大学洛杉矶分校,博士后
2010
10-20117月,美国加州大学洛杉矶分校,staff research associate Ⅲ
2011
7-今 中国科学院上海生命科学院植物生理生态研究所,研究员/课题组长

先后获得国家基金委“杰出青年基金”“优秀青年基金”国家自然科学基金重点课题,上海市“优秀学术带头人”“浦江人才”等项目资助。相关研究成果以通讯作者发表在Developmental Cell, Nature Plants, Nature Structure & Molecular Biology, EMBO J, PNAS, Plant Cell, EMBO R等国际期刊上。担任中国植物生理与分子生物学学会女科学家分会副会长,The Plant CellJIPBPlant CommunicationaBiotechFrontiers Plant Science杂志编委。

研究工作

不断变换的光照条件并对之做出相应反应是生物的基本特征。光对于植物尤为重要,不仅仅因为光是植物光合作用的能量来源,同时也因为光是非常重要的环境信号,调节植物的生长发育。所以植物如何对光做出反应以及光信号的传递机制是生物研究中最重要最基本的问题之一。实验室以拟南芥和玉米为对象,围绕光信号调控植物发育的分子机制,光信号传递的机制,及光信号转导与其他内外源信号的交叉整合展开植物分子发育研究。

主要成果

1. 解析紫外光UV-B信号传递及其调控植物发育与抗紫外胁迫的机制 (EMBO J, 2020; The Plant Cell, 2020; Developmental Cell, 2018; Nature Plants, 2018)
2.
在蓝光与温度协同调控植物发育的机制研究方面取得进展(The Plant Cell, 2020; PNAS2016; Plant Cell, 2016)。
3
.系统解析蓝光信号调控光周期诱导开花的CRY2-CIBs途径(Nature Structure & Molecular Biology, 2020; New Phytologist, 2019; EMBO R, 2018; PLoS Genetics, 2013; PNAS2013)。

    1. Liang T#, Shi C#, Peng YTan HXin P, Yang Y, Wang F, Li X, Chu J, Huang JYin Y, Liu H*. (2020) Brassinosteroid-Activated BRI1-EMS-SUPPRESSOR 1 Inhibits Flavonoid Biosynthesis and Coordinates Growth and UV-B Stress Responses in Plants. The Plant Cell.  DOI: https://doi.org/10.1105/tpc.20.00048

     

    2. Xu Li#, Cuicui Liu#, Zhiwei Zhao, Dingbang Ma, Jinyu Zhang, Yu Yang, Yawen Liu, Hongtao Liu*. (2020) COR27 and COR28 are Novel Regulators of the COP1–HY5 Regulatory Hub and Photomorphogenesis in Arabidopsis. The Plant Cell. DOI: https://doi.org/10.1105/tpc.20.00195

     

    3. Shao K#, Zhang X#, Li X#, Hao Y, Huang X, Ma M, Zhang M, Yu F, Liu H*, Zhang P*. (2020) The oligomeric structures of plant cryptochromes. Nature Structure & Molecular Biology. 27: 472–479

     

    4. Yang Y, Liu H*. (2020) Coordinated shoot and root responses to light signaling in Arabidopsis. Plant Communications, DOI: 10.1016/j.xplc.2020.100026

     

    5. Yang Y, Zhang L, Chen P, Liang T, Li X, Liu H*. (2020) UVR8 interacts with MYB73/MYB77 in a UV-B-dependent manner, regulating auxin responses and lateral root development. EMBO Journal. doi/10.15252/embj.2019101928

     

    6. Wang F, Yuan Z, Zhao Z, Li C, Zhang X, Liang H, Liu Y, Xu Q, Liu H*. (2019) Tasselseed5 of maize is a cytochrome C oxidase that affecting jasmonate catabolism in sex determination. Journal of Integrative Plant Biology. https://doi.org/10.1111/jipb.12826

     

    7. Wang F#, Gao Y#, Liu Y#, Zhang X, Gu X, Ma D, Zhao Z, Yuan Z, Xue H and Liu H*. (2019) BES1 regulated BEE1 controls photoperiodic flowering downstream of blue light signaling pathway in Arabidopsis New Phytologist. DOI: 10.1111/nph.15866

     

    8. Liang T, Mei S, Shi C, Yang Y, Peng Y, Ma L, Wang F, Li X, Huang X, Yin Y, Liu H*. (2018) UVR8 interacts with BES1 and BIM1 to regulate transcription and photomorphogenesis in Arabidopsis. Developmental Cell. 44:1-12

     

    9. Yang Y, Liang T, Zhang L, Shao K, Gu X, Shang R, Shi N, Li X, Zhang P, Liu H*. (2018) UVR8 interacts with WRKY36 to regulate HY5 transcription and hypocotyl elongation in Arabidopsis. Nature Plants. 4:98-107

     

    10. Li X, Cai W, Liu Y, Li H, Fu L, Liu Z, Xu L, Liu H, Xu T, Xiong Y* (2017) Differential TOR activation and cell proliferation in Arabidopsis root and shoot apexes. Proc Natl Acad Sci U S A. 114(10):2765-2770

    11. Reqing He#, Xinmei Li#, Ming Zhong#, Jindong Yan, Ronghuang Ji, Xu Li, Qin Wang, Dan Wu, Mengsi Sun, Dongying Tang, Jianzhong Lin, Hongyu Li, Bin Liu, Hongtao Liu, Xuanming Liu*, Xiaoying Zhao*, Chentao Lin, A photo-responsive F-box protein FOF2 regulates floral initiation by promoting FLC expression in Arabidopsis. The Plant Journal, 2017, 91, 788-801

     

    12. Li X#, Ma D#, Lu S#, Hu X, Huang R, Liang T, Xu T, Tobin E, Liu H*. (2016) Blue Light- and Low Temperature-Regulated COR27 and COR28 Play Roles in the Arabidopsis Circadian Clock. The Plant Cell. 28(11):2755-2769.

     

    13. Ma D#, Li X#, Guo Y, Chu J, Fang S, Yan C, Noel J, Liu H*. (2016) Cryptochrome 1 interacts with PIF4 to regulate high temperature-mediated hypocotyl elongation in response to blue light. Proc Natl Acad Sci U S A. 113(1):224-9.

     

    14. Li L, Li X, Liu Y, Liu H*. (2016) Flowering responses to light and temperature. Sci China Life Science. doi:10.1007/s11427-015-4910-8

     

    15. Gao QF, Gu LL, Wang HQ, Fei CF, Fang X, Hussain J, Sun SJ, Dong JY, Liu H, Wang YF*. (2016) Cyclic nucleotide-gated channel 18 is an essential Ca2+ channel in pollen tube tips for pollen tube guidance to ovules in Arabidopsis. Proc Natl Acad Sci U S A. 113(11):3096-101.

     

    16. Zhang TQ, Lian H, Tang H, Dolezal K, Zhou CM, Yu S, Chen JH, Chen Q, Liu H, Ljung K, and Wang JW*. (2015) An intrinsic microRNA timer regulates progressive decline in shoot regenerative capacity in plants. The Plant Cell. 27(2):349-60.

     

    17. Tan ST, Dai C, Liu HT, and Xue HW*. (2013) Arabidopsis casein kinase1 proteins CK1.3 and CK1.4 phosphorylate cryptochrome 2 to regulate blue light signaling. The Plant Cell. 25: 2618-2632.

     

    18. Liu Y, Li X, Li K, Liu H*, Lin C (2013) Multiple bHLH proteins form heterodimers to mediate CRY2-dependent regulation of flowering-time in Arabidopsis, PLoS Genetics 9(10): e1003861

     

    19. Liu H*, Wang Q, Liu Y, Zhao X, Lin C* (2013) The Arabidopsis photoreceptors CRY2 and ZTL mediate blue-light regulation of the transcription factor CIB1 by distinct mechanisms. Proc Natl Acad Sci U S A 4317582-17587

     

    20. Liu H*, GomezG, Lin S, Lin S, Lin C (2012) Optogenetic control of transcription in zebrafish. PLoS One. 2012;7(11):e50738.

     

    21. Wang Q, Fristedt R, Yu X, Chen Z, Liu H et al (2012). The γ-carbonic anhydrase subcomplex of mitochondrial complex I is essential for development and important for photomorphogenesis of Arabidopsis. Plant Physiology. doi: http://dx.doi.org/10.1104/pp.112

     

    22. Li X, Wang Q, Yu X, Liu H, Yang H et al (2011) Arabidopsis cryptochrome 2 (CRY2) functions by the photoactivation mechanism distinct from the tryptophan (trp) triad-dependent photoreduction. Proc Natl Acad Sci U S A 108(51):20844-20849.

     

    23. Liu H, Liu B. Zhao C, Pepper M and Lin C (2011). The action mechanisms of plant cryptochromes, Trends in Plant Sciences,16:684-691.

     

    24. Lu S#, Liu H#, Knowles S, Li J, Ma L, Tobin E, Lin C. (2011). A role for protein kinase CK2 alpha subunits in the Arabidopsis circadian clock. Plant Physiology 157: 1537-1545

     

    25. Zuo Z#, Liu H#, Liu B#, Liu X, Lin C.(2011) Blue Light-Dependent Interaction of CRY2 with SPA1 Regulates COP1 activity and Floral Initiation in Arabidopsis. (co-first author) Current Biology 21:841-847

     

    26. Liu B, Zuo Z, Liu H, Lin C. (2011). Arabidopsis cryptochrome 1 interacts with SPA1 to suppress COP1 activity in response to blue light. Gene & Development 25:1004-1009

     

    27. Liu B, Liu H, Zhong D, and Lin C. (2010). Searching for a photocycle of the Cryptochromephotoreceptors. Current Opinion in Plant Biology 13:1-9

     

    28. Liu H, Yu X, Li K, Klejnot J, Yang H, Lisiero D, Lin C. (2008). Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis. Science 322:1535-1539.

     

    29. Liu HT, Gao F, Li GL, Han JL, Liu DL, Sun DY, Zhou RG. (2008). The calmodulin-binding protein kinase 3 is part of heat-shock signal transduction in Arabidopsis thaliana. The Plant Journal 55(5):760-73.

     

    30. Liu HT, Li GL, Chang H, Sun DY, Zhou RG, Li B. (2007). Calmodulin-binding protein phosphatase PP7 is involved in thermotolerance in Arabidopsis. Plant Cell & Enviroment 30(2):156-64.

     

    31. Liu HT#, Gao F#, Sun DY, Zhou RG. (2006). Primary evidence for involvement of IP3 in heat-shock signal transduction in Arabidopsis. Cell Research 16(4):394-400

     

    32.Liu HT, Sun DY, Zhou RG. (2005). Ca2+ and AtCaM3 are Involved in the Expression of Heat Shock Protein Gene in Arabidopsis. Plant Cell & Environment 28:1276-1284.

     

    33. Li B, Liu HTSun DY, Zhou RG. (2004). Ca2+ and Calmodulin modulate DNA-binding activity of maize heat shock transcription factor in vitro. Plant Cell Physiology 45(5): 627-634.

     

    34. Liu HTLi B, Shang ZL, Mu RL Sun DY, Zhou RG. (2003). Calmodulin is involved in heat shock signal transduction in wheat. Plant Physiology 132(7): 1186-1195