个人信息

博士生导师
Principal Investigator

Email: jmurray@cemps.ac.cn
个人网页:

研究方向

Beneficial Plant-Microbe Interaction Research

Jeremy Murray

个人简介

2017-present CEPAMS, Institute of Plant Physiology & Ecology, CAS, Principal Investigator, Shanghai, China
2010-2017 John Innes Centre, Group leader, Norwich, UK
2006-2009 The Noble Institute, Oklahoma, USA,Postdoc
2003-2006 SCPFRC, London, Canada, Postdoc
1998-2003 PhD University of Guelph, Guelph, Canada
1993-1997 MSc University of Western Ontario, London, Canada
1989-1993 BSc Dalhousie University, Halifax, Canada

研究工作

Our research seeks to uncover the molecular mechanisms underlying symbiotic infection of plants by beneficial microbes. To do this we are studying the processes underlying infection of plant roots by rhizobia and arbuscular mycorrhiza. Rhizobia are N-fixing bacteria that colonize the roots of plants to form an endosymbiosis with legumes in which fixed N is provided to the host plant in specialized organs called nodules. This symbiosis, called nodulation, has evolved from a more ancient interaction that arbuscular mycorrhizal fungi form with most land plants. In order to understand how these microbes are accommodated by the host plant we will identify host components required for the colonization of plant roots and the formation of intracellular infection structures.

主要成果

The key contributions of our lab include the identification of numerous genes required for infection by rhizobia and arbuscular mycorrhiza. We showed that cytokinin and auxin are required for nodule formation amd that cytokinin signalling negatively effects rhizobial infection (5, 10). One of these genes, VAPYRIN, was the first structural gene identified to be required for infection of both rhizobia and arbuscular mycorrhizal fungi (9). Using VAPYRIN as a marker, we identified a novel subcellular structure which we have named the infectosome, which is associated with the polar growth of rhizobial infection threads (3). We further used transcriptomics studies to discover that genes associated with cell cycle activation are induced during infection of root hairs by rhizobia (4, 8). We have recently shown that the susceptibility gene MLO plays a role in infection by arbuscular mycorrhiza (1).

    1. Jacott C, Charpentier M, Murray JD*, and Ridout C*. (2020) Mildew Locus O facilitates colonization by arbuscular mycorrhizal fungi in angiosperms. New Phytol. 227(2):343-351; https://nph.onlinelibrary.wiley.com/doi/abs/10.1111/nph.16465.

    2. Kumar A, Cousins DR, Liu CW, Xu P, Murray JD*. (2020) Nodule Inception Is Not Required for Arbuscular Mycorrhizal Colonization of Medicago truncatula. Plants (Basel). 9(1), 71; https://www.mdpi.com/2223-7747/9/1/71.

    3. Liu CW, Breakspear A, Stacey N, Findlay K, Nakashima J, Ramakrishnan K, Liu MX, Xie F, Endre G, Niebel FC, Oldroyd GED, Udvardi MK, Fournier J*, Murray JD*. (2019) A protein complex required for polar growth of rhizobial infection threads. Nature Communications. 10:2828; https://www.nature.com/articles/s41467-019-10029-y.

    4. Liu CW, Breakspear A, Guan D, Cerri MR, Jackson K, Jiang SY, Robson F, Radhakrishnan GV, Roy S, Bone C,  Stacey N, Rogers C, Trick M, Niebel A,  Oldroyd GED,  Carvalho-Niebel F,  Murray JD*. (2019) NIN Acts as a Network Hub Controlling a Growth Module Required for Rhizobial Infection. Plant Physiology. 179:1704-1722; http://www.plantphysiol.org/content/179/4/1704.long.

    5. Roy S, Robson F, Lilley J, Liu CW, Cheng X, Wen J, Walker S, Sun J, Cousins D, Bone C, Bennett MJ, Downie JA, Swarup R, Oldroyd G, Murray JD*. (2017) MtLAX2, a Functional Homologue of the Arabidopsis Auxin Influx Transporter AUX1, Is Required for Nodule Organogenesis. Plant Physiol. 174: 326-338; http://www.plantphysiol.org/content/174/1/326.

    6. Murray JD*, Liu CW, Chen Y, Miller AJ*. (2017) Nitrogen sensing in legumes. J Exp Bot. 68(8): 1919-1926; (Review) https://academic.oup.com/jxb/article/68/8/1919/2645554.

    7. Liu CW, Murray JD* (2016) The Role of Flavonoids in Nodulation Host-Range Specificity: An Update. Plants (Basel). 5(3): 33; (Review) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5039741/.

    8. Breakspear A, Liu CW, Roy S, Stacey N, Rogers C, Trick M, Morieri G, Mysore KS, Wen JQ, Oldroyd GED, Downie JA, Murray JD*. (2014) The root hair ‘Infectome’ of Medicago truncatula uncovers changes in cell cycle genes and reveals a requirement for auxin signalling in rhizobial infection. Plant Cell. 26:4680-701; http://www.plantcell.org/content/26/12/4680.

    9. Murray JD, Muni RR, Torres-Jerez I, Tang Y, Allen S, Andriankaja M, Li G, Laxmi A, Cheng X, Wen J, Vaughan D, Schultze M, Sun J, Charpentier M, Oldroyd G, Tadege M, Ratet P, Mysore KS, Chen R, Udvardi MK*. (2011) Vapyrin, a gene essential for intracellular progression of arbuscular mycorrhizal symbiosis, is also essential for infection by rhizobia in the nodule symbiosis of Medicago truncatula. Plant J. 65:244-52; https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-313X.2010.04415.x.

    10. Murray JD, Karas BJ, Sato S, Tabata S, Amyot L, and Szczyglowski K*. (2007) A cytokinin perception mutant colonized by rhizobium in the absence of nodule organogenesis. Science. 315:101-104; http://science.sciencemag.org/content/315/5808/101/tab-pdf.