Beneficial Plant-Microbe Interaction Research
2017-present CEPAMS, Institute of Plant Physiology & Ecology, CAS, Principal Investigator, Shanghai, China
2010-2017 John Innes Centre, Group leader, Norwich, UK
2006-2009 The Noble Institute, Oklahoma, USA，Postdoc
2003-2006 SCPFRC, London, Canada, Postdoc
1998-2003 PhD University of Guelph, Guelph, Canada
1993-1997 MSc University of Western Ontario, London, Canada
1989-1993 BSc Dalhousie University, Halifax, Canada
Our research seeks to uncover the molecular mechanisms underlying symbiotic infection of plants by beneficial microbes. To do this we are studying the processes underlying infection of plant roots by rhizobia and arbuscular mycorrhiza. Rhizobia are N-fixing bacteria that colonize the roots of plants to form an endosymbiosis with legumes in which fixed N is provided to the host plant in specialized organs called nodules. This symbiosis, called nodulation, has evolved from a more ancient interaction that arbuscular mycorrhizal fungi form with most land plants. In order to understand how these microbes are accommodated by the host plant we will identify host components required for the colonization of plant roots and the formation of intracellular infection structures.
The key contributions of our lab include the identification of numerous genes required for infection by rhizobia and arbuscular mycorrhiza. We showed that cytokinin and auxin are required for nodule formation amd that cytokinin signalling negatively effects rhizobial infection (5, 10). One of these genes, VAPYRIN, was the first structural gene identified to be required for infection of both rhizobia and arbuscular mycorrhizal fungi (9). Using VAPYRIN as a marker, we identified a novel subcellular structure which we have named the infectosome, which is associated with the polar growth of rhizobial infection threads (3). We further used transcriptomics studies to discover that genes associated with cell cycle activation are induced during infection of root hairs by rhizobia (4, 8). We have recently shown that the susceptibility gene MLO plays a role in infection by arbuscular mycorrhiza (1).